Formulation of inhalable lipid-based salbutamol sulfate microparticles by spray drying technique

Formulation and in Vitro Evaluation of Famotidine Floating Tablets by Lipid Solid Dispersion Spray Drying Technique

The purpose of this investigation was to prepare a gastro retentive drug delivery system of famotidine tablets. Floating tablets of famotidine were prepared employing lipid solid dispersion spray drying technique with gelucire 50/13 and compritol 888 along with HPMC K100M, lactose, sodium bicarbonate and citric acid. The floating tablets were evaluated for uniformity of weight, hardness, friabi...

solid lipid microparticles of salbutamol sulfate for dry powder inhalation

Development of Biodegradable Polycation-Based Inhalable Dry Gene Powders by Spray Freeze Drying

In this study, two types of biodegradable polycation (PAsp(DET) homopolymer and PEG-PAsp(DET) copolymer) were applied as vectors for inhalable dry gene powders prepared by spray freeze drying (SFD). The prepared dry gene powders had spherical and porous structures with a 5~10-μm diameter, and the integrity of plasmid DNA could be maintained during powder production. Furthermore, it was clarifie...

Alginate microparticles produced by spray-drying for oral insulin delivery

In spite of the prevalence of subcutaneous injections for insulin administration, there are several concerns associated with this mode of administration including injection anxiety, pain, cost, infection, and as a result an overall decrease in patient compliance (Khafagy 2007). This has prompted researchers to search for alternative delivery methods including transdermal, nasal, pulmonary, rect...

Inhalable nanocomposite microparticles: preparation, characterization and factors affecting formulation.

INTRODUCTION Nanocomposite microparticles are intelligent carriers utilised for pulmonary drug delivery. These carriers are composed of drug-encapsulated nanoparticles dispersed in microstructures of polysaccharides. Upon administration, the inhaled microparticles can penetrate and be deposited deeply in the lung due to their adjusted aerodynamic particle size. Subsequently, the nanoparticles a...